@InProceedings{Richter:Will:Backofen:Metallobiolomics2007, author = {Richter, Andreas S. and Will, Sebastian and Backofen, Rolf}, title = {A Sampling Approach for the Exploration of Biopolymer Energy Landscapes}, booktitle = {Proceedings of the European Conference on Metallobiolomics (HMI Berlin, Germany, 2007)}, editor = {Kyriakopoulos, Antonios and Michalke, Bernhard and Graebert, Alexandra and Beschnidt, Gabriele }, publisher = {Herbert Utz Verlag, M\"unchen}, year = {2008}, pages = {27-38}, abstract = {The folding of biopolymers is crucially determined by the properties and the topology of the underlying energy landscape. A reduced representation of these energy landscapes is provided by barrier trees, which can be used to study the dynamical behavior of the folding. We presented a generic, problem-independent approach for the generation of barrier trees of discrete biopolymer models. In contrast to previous studies, the approach used does not rely on enumeration, which is limited to smaller molecules due to the amount of available memory. The algorithm has been applied to RNA and a lattice protein. The results show that the approach can be used to compute both all local minima and the exact barrier tree of an energy landscape. The presented method does not restrict the investigated conformation space to certain regions.}, user = {arichter} }